HOME > FOR BUSINESS > R&D projects > R&D at IBiB PAS

R&D Projects at IBiB PAN

Development of a wide-porous scaffold manufacturing method for culturing of chondrocytes designed for bio-artificial implants

Budget: 518 000 PLN; Contract number: N N518 4058 33

Articular cartilage which covers the distal part of bones has a very limited capacity for regeneration. The purpose of the project was to repair the full-thickness articular cartilage defects in rabbits’ knee joints. Applied method used the high porous polyethersulfone membrane to culture the autologous chondrocytes. The results of the project showed clearly that this method was effective in repairing of articular cartilage defect. The 3D membranes seem to be effective scaffold for cultivation of other types of cells.


Model center of diabetes treatment integrating innovatory systems including telematic ones, aimed at technical support of the patient's state monitoring, treatment, education and screening

Budget: 1 080 000 PLN; Contract number: R13 02302

The objective of the project was to design and develop a system called Model Center of Diabetes Treatment (MCDT). This model center integrates innovative, effective, telemedicine systems aiming at technical support of monitoring and treatment of diabetes, educating the diabetic patients as well as screening for diabetic retinopathy. Primary structure ofthe center bases on four specialized modules, the central educational unit and the screening unit. Particular specialized modules are devoted to treatment of: (1) cardio-diabetological complications, (2) the Diabetic Foot Syndrome, (3) diabetes during pregnancy (gestational and type 1 diabetes) and (4) .difficult diabetes.. Software of the center that was developed can serve as a modern, replicable solution for medical care supported with a telematic technique (home and mobile telecare).


Usage of the high resolution ECG maps in non-invasive diagnostics of the coronary heart disease and in assessment of the heart viability

Budget: 520 000 PLN; Contract number: N N518 504 339; Period: 16.09.2010-15.03.2013

The project is aimed at research and development of new methods for high resolution measurements and multi-parameters analysis of the cardiac electrical field.  It is oriented to non-invasive early detection of ischaemic heart disease and myocardial viability assessment.  The study group will consist of 100-120 patients with ischemic heart failure. Diagnostic value of developed methods will be verified by independent SPECT and coronarography examination.


Development of a novel diagnostic system for non invasive assessment of the blood microcirculation applying the laser-doppler method

Budget: 1 300 000 PLN; Contract number: R13 034 01; Period: 22.09.2006 - 31.03.2010

The aim of the project was advanced research and development of non-invasive diagnostic setup for measurements of blood microcirculation in microvascular net with application utilization of laser Doppler technique. As a result of the project, improvement of the following laser Doppler technique aspects was achieved: instrument calibration methods, methods of signal processing and analysis, development of a new method of laser Doppler spectra decomposition for assessment of blood speed distributions and design of integrated measurement optodes. A prototype of computerized laser Doppler diagnostic setup was developed and its complex technical studies were performed. The instrument was validated in clinical studies, where 50 patients with different microcirculation disorders and diabetes were examined.


Development of the respirator prototype: design, realization and laboratory tests

Budget: 657 000 PLN; Contract number: R13 0032 04

In the frame of this project a new type of the lung respirator has been designed and built up. The main feature of the respirator is an original ventilation strategy which can be described by the modified power function. This function links inspiratory flow and pressure with inspiratory power. One can obtain different modes of lung ventilation: constant power ventilation, and constant pressure ventilation. It can be easily proved that the respiratory algorithm includes an inherited mechanism in great part automatically compensating lungs resistance changes. During expiration a biofeedback mechanism is applied, automatically compensating an intubation tube resistance and so diminishing a lungs muscles effort.


Hybrid (physical-numerical) model of cardio-pulmonary interaction

Budget: 375 000 PLN

The main goal of works done in the frame of the grant has been created of a hybrid physical . numerical model able to be directly connected with medical lung assist devices e.g. respirators, VADs, an IABPs. So defined task has been based on the complex mathematical . numerical model of the cardiopulmonary interaction.The numerical environment of the mathematical model is connected with the physical environment of the assist devices by means of special interfaces playing a role of pneumo-numerical or hydro-numerical impedance transformers IT. Applying IT one can connect the particular assist device to any point of the numerical cardiopulmonary interaction model.


e-Hepar. information system for early diagnosis and prediction of the liver tumors progression

Budget: 825 000 PLN; Contract number: N R13 0014 04

The project aims to develop new methods for exploratory data analysis and their implementation in a prototype version of an information system "e-Hepar" to promote early diagnosis, prediction and prevention of cancer diseases of the liver. The system will support such early diagnosis of liver cirrhosis, forecasting its evolution towards heart failure and early diagnosis of primary hepatocellular carcinoma (hepatocellular carcinoma, HCC). The project also envisages construction of a pilot version of the information system with the access to it via the Internet (e-Hepar). Such a system is designed to provide wider services for early diagnosis, prediction of selected neoplastic diseases of the liver and postgraduate medical training. The main part of the services offered by the system will be addressed to the GP with the

patient, eg for family doctors.


Non-invasive imaging of brain function and disease by pulsed near infrared light (nEUROPt)

Total Budget: 7 529 109 EURO; Contract number: HEALTH-2007; EU participation: 5 738 653 EURO;

Contract number: FP7-HEALTH; Period: 01.04.2008-31.03.2012

The project aims at the development and clinical validation of advanced non-invasive optical methodologies for in-vivo diagnosis, monitoring, and prognosis of major neurological diseases (stroke, epilepsy, ischemia), based on diffuse optical imaging by pulsed near infrared light. Diffuse optical imaging is expected to provide a valuable complementing tool to assess perfusion and blood oxygenation in brain tissue and their time evolution in a continuous or quasi-continuous manner. The devices will be portable and comparably inexpensive and can be applied in adults and in children. IBIB PAS is involved in the project as one of the key technical partners who develop instrumentation and carry clinical tests in collaboration with their clinical partners. IBIB coordinates the studies related to the processing of

optical time-resolved data acquired during clinical trials. IBIB developed also instrumentation used in clinical tests carried out together with the Warsaw Medical University. These tests are aimed on validation of optical time-resolved technique in bed-side assessment of brain perfusion and oxygenation in critically ill patients. IBIB is also involved in basic investigation related to the signal processing techniques and methodology of estimation of optical properties of tissues.


Micro- and nano-systems in chemistry and biomedical diagnostics (MNS-DIAG)

A. Miniature lab-on-a-chip systems with electrochemical detection for psychoactive substances determination in saliva, E-LOC

Contract number: POIG 01.03.01-00-014/08-01 1A

Budget: 1 065 000 PLN

Aim of this project is to develop the lab-on-a-chip with electrochemical detection for tricyclic antidepressants (TCA) that belong to the group of psychotropic drugs. Amperometric sensors with different electrode materials such as: thin-film platinum and gold, thick-film graphite, carbon, carbon mediated and other are modified, optimized and investigated. Since it is expected a very low concentration of the TCA that will be measured in a very complex matrix of saliva sample, an extra module was proposed. Namely, to increase the selectivity as well as to pre-concentrate the TCA in a sample, microchips for capillary electrophoresis (CE) have been designed and fabricated in a glass/polydimethylsiloxane (PDMS) technology. 

B. Bio-microreactors for cell culturing, BioRK

Contract number: POIG 01.03.01-00-014/08-01 3

Budget: 1 230 000 PLN

Micro-bioreactors are designed as a research tool for tissue engineering, which might be used for optimization of conditions for cell culturing. Research is focused on investigation of different materials as a support for cell culturing. Since diamond-like carbon (DLC) is considered as a biocompatible material, this material was chosen as the substrates for cell culture. Then, the hydrophobic diamond like carbon surfaces of different texture were tested as substrates for human hepatoma C3A cell line culturing.


SensorART: A remote controlled Sensorized ARTificial heart enabling patients empowerment and new therapy approaches.

Budget: 374.880 EU ; Contract number : 248763

In the frame of the SensorART project, our Lab. is responsible for realization of two main tasks: designing and manufacturing of a VAD – Heart Simulation Platform and the related training of a medical staff.

The four TR modules (blocks) are functionally independent and allow connecting of any physical hydraulic units (e.g. LVAD, IABP, artificial valves etc.) to any chosen point of the numerical circulatory model according to experimental needs.

In the Real-Time computer a software simulating circulatory system will be run especially developed by IBBE-PAS. Simulated data (the left atrial and ventricular pressures, aortic pressure etc.) under several circulatory conditions as well as the flow produced by assisting continuous flow pump by CircuLite will be stored in hard-drive and used by the Decision Support System.


Remote detection and identification of biological contamination utilizing advanced optoelectronic methods

IBIB Contract number: G 007/T02/2007

The goal of this project was development of the micro flow cytometer - demonstrator for detection of biological pollutions. The geometry and hydrodynamic properties of the microfluidic system were optimized in COMSOL and fabricated in soft lithography with use of elastomer polydimethylsiloxane (PDMS). For preliminary tests of the developed optical detection system controlled by LabView (NI), a standard fluorescent dye - sodium fluorescein (SF) was used; the low detection limit for SF was ca. 1 µg/ml (2.7 µM).



BioCentrum Ochota

Instytut Biochemii i Biofizyki PAN Instytut Biologii Doświadczalnej im. M. Nenckiego PAN Instytut Medycyny Doświadczalnej i Klinicznej PAN Isntytut Biocybernetyki i Inżynierii Biomedycznej PAN Instytut Podstawowych Problemów Techniki PAN

Project co-financed by the European Union from the European Social Fund within the Human Capital Operational Programme 2007-2013
Niniejszy serwis nie zbiera w sposób automatyczny żadnych informacji, za wyjątkiem informacji zawartych w plikach cookies. Przez używanie stron niniejszego serwisu wyrażasz zgodę na używanie ciasteczek zgodnie z naszą polityką. Jeżeli nie zgadzasz się na stosowanie cookies przez nasz serwis, powinieneś zmienić ustawienia swojej przeglądarki w odpowiedni sposób lub zrezygnować z używania stron tej witryny. X